Susceptibility to flavivirus-specific antiviral response of Oas1b affects the neurovirulence of the Far-Eastern subtype of tick-borne encephalitis virus
Identifieur interne : 001E16 ( Main/Exploration ); précédent : 001E15; suivant : 001E17Susceptibility to flavivirus-specific antiviral response of Oas1b affects the neurovirulence of the Far-Eastern subtype of tick-borne encephalitis virus
Auteurs : Kentaro Yoshii [Japon] ; Kanako Moritoh [Japon] ; Noriyo Nagata [Japon] ; Kana Yokozawa [Japon] ; Mizuki Sakai [Japon] ; Nobuya Sasaki [Japon] ; Hiroaki Kariwa [Japon] ; Takashi Agui [Japon] ; Ikuo Takashima [Japon]Source :
- Archives of Virology [ 0304-8608 ] ; 2013-05-01.
Abstract
Abstract: Tick-borne encephalitis virus (TBEV) is a zoonotic agent that causes fatal encephalitis in humans. 2’-5’-oligoadenylate synthetase 1b (Oas1b) has been identified as a flavivirus resistance gene, but most inbred laboratory mice do not possess a functional Oas1b gene. In this study, a congenic strain carrying a functional Oas1b gene, B6.MSM-Oas, was used to evaluate the pathogenicity of Far-Eastern TBEV. Although intracerebral infection of B6.MSM-Oas mice by Oshima 5-10 resulted in limited signs of illness, infection by Sofjin-HO resulted in death with severe neurologic signs. While Oshima 5-10 was cleared from the brain, Sofjin-HO was not cleared despite a similar level of expression of the intact Oas1b gene. Necrotic neurons with viral antigens and inflammatory reactions were observed in the brain infected with Sofjin-HO. These data indicate that the different susceptibility to the antiviral activity of Oas1b resulted in a difference in neurovirulence in the two TBEV strains.
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DOI: 10.1007/s00705-012-1579-1
Affiliations:
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ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Tick-borne encephalitis virus (TBEV) is a zoonotic agent that causes fatal encephalitis in humans. 2’-5’-oligoadenylate synthetase 1b (Oas1b) has been identified as a flavivirus resistance gene, but most inbred laboratory mice do not possess a functional Oas1b gene. In this study, a congenic strain carrying a functional Oas1b gene, B6.MSM-Oas, was used to evaluate the pathogenicity of Far-Eastern TBEV. Although intracerebral infection of B6.MSM-Oas mice by Oshima 5-10 resulted in limited signs of illness, infection by Sofjin-HO resulted in death with severe neurologic signs. While Oshima 5-10 was cleared from the brain, Sofjin-HO was not cleared despite a similar level of expression of the intact Oas1b gene. Necrotic neurons with viral antigens and inflammatory reactions were observed in the brain infected with Sofjin-HO. These data indicate that the different susceptibility to the antiviral activity of Oas1b resulted in a difference in neurovirulence in the two TBEV strains.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><noRegion><name sortKey="Yoshii, Kentaro" sort="Yoshii, Kentaro" uniqKey="Yoshii K" first="Kentaro" last="Yoshii">Kentaro Yoshii</name></noRegion><name sortKey="Agui, Takashi" sort="Agui, Takashi" uniqKey="Agui T" first="Takashi" last="Agui">Takashi Agui</name><name sortKey="Kariwa, Hiroaki" sort="Kariwa, Hiroaki" uniqKey="Kariwa H" first="Hiroaki" last="Kariwa">Hiroaki Kariwa</name><name sortKey="Moritoh, Kanako" sort="Moritoh, Kanako" uniqKey="Moritoh K" first="Kanako" last="Moritoh">Kanako Moritoh</name><name sortKey="Nagata, Noriyo" sort="Nagata, Noriyo" uniqKey="Nagata N" first="Noriyo" last="Nagata">Noriyo Nagata</name><name sortKey="Sakai, Mizuki" sort="Sakai, Mizuki" uniqKey="Sakai M" first="Mizuki" last="Sakai">Mizuki Sakai</name><name sortKey="Sasaki, Nobuya" sort="Sasaki, Nobuya" uniqKey="Sasaki N" first="Nobuya" last="Sasaki">Nobuya Sasaki</name><name sortKey="Takashima, Ikuo" sort="Takashima, Ikuo" uniqKey="Takashima I" first="Ikuo" last="Takashima">Ikuo Takashima</name><name sortKey="Yokozawa, Kana" sort="Yokozawa, Kana" uniqKey="Yokozawa K" first="Kana" last="Yokozawa">Kana Yokozawa</name><name sortKey="Yoshii, Kentaro" sort="Yoshii, Kentaro" uniqKey="Yoshii K" first="Kentaro" last="Yoshii">Kentaro Yoshii</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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